February 11, 2025
Unchained Labs Catalogue
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Unchained Labs
Here’s the deal. We’re all about helping biologics and gene therapy researchers break free from tools that just don’t cut it. Unleashing problem-tackling solutions that make a huge difference in the real science they do every day. That’s our mantra, our promise and we own it.
Biologics are big, finicky molecules that need a fine-tuned structure and formulation to remain stable and effective. From day one, our calling has been to provide real solutions to challenging tasks like measuring concentration, screening for stability and aggregation and performing buffer exchange – key steps on the path to the best biologic.
Aunty
Aunty is the fastest and highest throughput protein stability characterization tool on the planet. Period. With unrivaled fluorescence, Static Light Scattering (SLS) and Dynamic Light Scattering (DLS) skills, Aunty blasts through thermal melting and aggregation experiments — reading an entire 96-well plate of samples every minute of a thermal ramp. Sift through piles of candidates, conditions, or formulations, with as many replicates as you want. Aunty cranks out plates of results with unprecedented data resolution, so you can find your winners at breakneck speed.
Stunner
Stunner is the only system out there that takes RADLS measurements and pairs them up with UV/Vis concentration from the same sample in the same run. Check concentration, hydrodynamic size, polydispersity, particle count and detection of aggregates off your to-do list in one shot – using only 2 µL of sample. And concentration measurements are spot-on with accuracy within 2% and precision within 1%.
Lunatic
Lunatic makes batch quantification of biologics, DNA and RNA a no-brainer. All you need is 2 µL and 10 minutes to measure up to 96 samples. Run them straight-up, even at high concentrations, without ever diluting. Measurements are spot-on with accuracy within 2% and precision within 1% and are fully compliant with USP and Ph. Eur. guidelines. The SBS plate-based format means integrating with lab automation and liquid handlers is a snap. Lunatic gets UV/Vis quantification on the money every time. Just drop, load and ready
Leprechaun
Leprechaun is the only system that hunts down viral titer by double-checking if particles are the right size and have the right structure - in crude or pure samples. Leprechaun’s single particle interferometry uses the signal enhancing silicon dioxide surface of the Luni consumable to maximize interference of light reflected from the Luni surface and scattered by the captured virus. This results in high resolution sizing of single particles, down to 35 nm in diameter. Establishing viral size allows Leprechaun to separate viral fragments and aggregates from single lentiviral particles with all the parts.
Sunscreen
Finding the perfect LNP formulation can feel like it drags on forever. You need to figure out the best lipid mixture, the right lipid to payload ratio and the optimal flow rates to mix it all together. Worst of all, it’s usually done one experiment at a time. Sunscreen totally flips the script by creating 96 unique, small volume LNP formulations in less than 6 hours – so you can explore more formulations in a single day than you ever thought was possible.
Sunshine
Once you’ve found a rock-solid formulation, Sunshine helps you tune in your LNP’s size and design the perfect process to scale them up. Scout ideal flow rates, explore different mixing options, then dial in the right dilution factor to keep them stable. When you’ve got everything just right, Sunshine can shift into continuous mode, making tens of liters in a day. Get process development and scale-up on one platform
Sunbather
Transferring your LNPs to GMP can be a costly, messy process. It usually means switching equipment, using a different flow path and mixer — basically a painful re-development and re-validation of all your hard work. Sunbather makes the move to GMP a walk in the park with the documentation, replaceable flow path and easy transfer built right in. It uses the same mixing process and protocol as its Sunny Suite family members Sunscreen and Sunshine, so you can take your dialed in formulation into GMP without all the fuss.
Honeybun
Honeybun is the only rapid viscosity system that pours out data as fast as you can handle it. Whether you’ve got one sample or ten, Honeybun sips microliters of each sample through a microfluidic channel to get a read on viscosity in minutes – with zero sample prep or clean-up. Ditch old school, one-at-a-time techniques that use too much sample and level up to the quickest, low-volume viscosity measurements out there.
Unagi
Buffer exchange and concentration are two of the most annoying things you have to do before you can work with your sample. It takes forever, you physically have to be there and just when you think it’s done, you’re tweaking it again, even for a handful of samples. Unagi is the first completely hands-free benchtop buffer exchange solution that’s made to take this not-so-fun task off your plate — so you can be anywhere else instead of tied to your bench.
Big Tuna
Buffer exchange and sample concentration are the time consuming, hands-on chores you must deal with before all the things you really want to do. Big Tuna is a fully automated, plate-based buffer exchange platform that uses a modified UF/DF method and gentle mixing to buffer exchange, concentrate, and clean up proteins, nucleic acids, or gene therapy vectors like AAVs and LNPs. Skip the slow and manual ways of prepping samples to free yourself up for other critical work.
Junior
Junior automates all your hands-on, back and forth and hard to do work. Explore more reaction and formulation conditions, prep samples, whatever task you think would be better performed if you’re not the one doing it. Every Junior benchtop automation platform is configurable to be just what you need. Work with our team to configure a system with tools that are battle tested from dozens of systems before you, or forge your own path and customize and automate something that’s never been done before. Either way, Junior is up to the task.
Big Kahuna
Big Kahuna gives you automated, high-throughput, end-to-end solutions for biologics, gene therapy vectors, small molecules, polymers and catalysts. It’s completely configurable and helps you save money and time while getting more work done. Take a look at how Big Kahuna can change the game for your workflow.
Products List
| Product Code | Product Name | Description |
| 221-1000 | 20 Aunty plates | 20 Aunty plates with seals |
| Product Code | Product Name | Description |
| 351-1001 | 10 Buns | Box of 10 Bun consumables. Each Bun measures up to 10 samples per run. |
| Product Code | Product Name | Description |
| 701-2013 | Lunatic Calibration Plate | Customer calibration plate for wavelength, position and pump calibration. For use with Lunatic. |
| 701-2015 | Little Lunatic Calibration Chips | Lunatic wavelength and positon calibration chips. For use with Little Lunatic or DropSense16. (Previously product code 1-30205) |
| 701-2027 | Performance verification cuvette plate | Lunatic/Stunner cuvette plate, no cuvettes included. Holds up to 8 cuvettes. Only compatible with UV/Vis performance verification. |
| Product Code | Product Name | Description |
| 701-2002 | Lunatic Plates, OD 40 (Box of 10) | Box of 10 Lunatic Plates, 0.03-40 OD. For use with Lunatic, DropSense96 or DropSense96 Classic. (Previously product code 4-210096-S) |
| 701-2005 | Lunatic Plate Frame Strips, OD 40 (Box of 30) | Box of 30 Lunatic Plate Frame Strips, 0.03-40 OD. 16 sample per chip. For use only with a reusable Lunatic Plate Frame and a Lunatic, DropSense96 or DropSense96 Classic platform. (Previously product code 4-230016-S) |
| 701-2006 | Lunatic Plate Frame Strips, OD 40 (Box of 480) | Box of 480 Lunatic Plate Frame Strips, 0.03-40 OD 16 samples per chip. For use only with a reusable Lunatic Plate Frame and a Lunatic, DropSense96 or DropSense96 Classic platform. (Previously product code 4-238016-S) |
| 701-2007 | High Lunatic Chips, OD 275 (Box of 25) | Box of 25 High Lunatic Chips, 0.03-275 OD. 16 samples per chip. For use with Little Lunatic or DropSense16. (Previously product code 1-230025-200) |
| 701-2008 | High Lunatic Chips, OD 275 (12 Boxes of 25) | 12 boxes of 25 High Lunatic Chips, 0.03-275 OD, 16 samples per chip. For use with Little Lunatic or DropSense16. (Previously product code 1-230300-200) |
| 701-2009 | Lunatic Chips, OD 40 (Box of 25) | Box of 25 Lunatic Chips, 0.03-40 OD. 16 samples per chip. For use with Little Lunatic or DropSense16. (Previously product code 1-230025-40) |
| 701-2010 | Lunatic Chips, OD 40 (12 Boxes of 25) | 12 boxes of 25 Lunatic Chips, 0.03-40 OD. 16 samples per chip. For use with Little Lunatic or DropSense16. (Previously product code 1-230300-40) |
| 701-2012 | Lunatic/Stunner Plate Frame | Lunatic/Stunner Plate frame. Holds up to 6 Lunatic Strips. For use with Stunner, Lunatic, DropSense96 or with LabChipDS or DropletQuant systems. On Stunner: Only compatible with UV/Vis. |
| 701-2018 | Lunatic/Stunner Verification standard | Potassium Dichromate Kit (1 mL verification standard, 3 glass vials). Used as verification standard for Lunatic, Stunner (SN <901999), and DropSense platforms. (Previously product code 1-301010) |
| 701-2019 | Lunatic Plates, OD 40 (Box of 40) | Box of 40 Lunatic Plates, 0.03-40 OD. 96 samples per plate. For use with Lunatic, DropSense96 or DropSense96 Classic. (Previously product code 4-240096-S) |
| 701-2029 | The Fundamentals | Kit to verify accuracy, precision, dynamic range and linearity. (500 µl verification standards, 5 glass vials) |
| 701-2100 | High Lunatic Plates, OD 275 (Box of 10) | Box of 10 High Lunatic Plates, 0.03-275 OD. 96 samples per plate. For use with Lunatic. (Lunatic & Stunner Client v8.3 or higher) |
| 701-2101 | High Lunatic Plates, OD 275 (Box of 40) | Box of 40 High Lunatic Plates, 0.03-275 OD. 96 samples per plate. For use with Lunatic (Lunatic & Stunner Client v8.3 or higher) |
| 701-2103 | High Lunatic Plate Frame Strips, OD 275 (Box of 30) | Box of 30 High Lunatic Plate Frame Strips, 0.03-275 OD. 16 samples per chip. For use only with a reusable Lunatic Plate Frame and Lunatic (Lunatic & Stunner Client v8.3 or higher) |
| 701-2104 | High Lunatic Plate Frame Strips, OD 275 (Box of 480) | Box of 480 High Lunatic Plate Frame Strips, 0.03-275 OD. 16 samples per chip. For use only with a reusable Lunatic Plate Frame and Lunatic (Lunatic & Stunner Client v8.3 or higher) |
| Product Code | Product Name | Description |
| 701-2032 | Stunner Calibration Kit | Customer calibration plate for wavelength, position, and pump calibration, and verification standard for RADLS (250 µL, 1 vial). |
| Product Code | Product Name | Description |
| 701-2012 | Lunatic/Stunner Plate Frame | Lunatic/Stunner Plate frame. Holds up to 6 Lunatic Strips. For use with Stunner, Lunatic, DropSense96 or with LabChipDS or DropletQuant systems. On Stunner: Only compatible with UV/Vis. |
| 701-2018 | Lunatic/Stunner Verification standard | Potassium Dichromate Kit (1 mL verification standard, 3 glass vials). Used as verification standard for Lunatic, Stunner (SN <901999), and DropSense platforms. (Previously product code 1-301010) |
| 701-2024 | Stunner Calibration Standard for DLS | DLS calibration standard (250 µL, 1 vial). Used as calibration standard in Stunner platforms with a serial number <901999. |
| 701-2030 | Stunner verification standard for RADLS | Used as size and intensity verification standard for Stunner. (1 vial, 250 µL) |
| 701-2031 | Stunner Calibration Plate | Stunner calibration plate for wavelength, position and pump calibration. |
| 701-2122 | Stunner Plates, Box of 40 | Box of 40 Stunner Plates, with DLS capability and OD range 0.03-275. 96 samples per plate. (Lunatic & Stunner Client v8.3 or higher) |
| 701-2125 | Stunner Plates, Box of 10 | Box of 10 Stunner Plates, with DLS capability and OD range 0.03-275. 96 samples per plate. (Lunatic & Stunner Client v8.3 or higher) |
| 701-2128 | Stunner Plate Frame strips, OD 275, UV/Vis only | Box of 30 Stunner Plate Frame Strips, 0.03-275 OD. 16 samples per chip. For use only for UV/Vis Experiments with reusable Stunner Plate Frame and Stunner platforms. Not compatible with DLS experiments. (Lunatic & Stunner Client v8.3 or higher) |
| Product Code | Product Name | Description |
| 901-2001 | Una RC, 10 kDa MWCO, case of 40 | Una consumable for Unagi instrument, 0.5 – 8 mL capacity. MWCO: 10kDa, regenerated cellulose (RC). 8 Unas per box, 5 boxes, case total of 40. |
| 901-2002 | Una RC, 30 kDa MWCO, case of 40 | Una consumable for Unagi instrument, 0.5 – 8 mL capacity. MWCO: 30kDa, regenerated cellulose (RC). 8 Unas per box, 5 boxes, case total of 40. |
| 901-2003 | Una RC, 100 kDa MWCO, case of 40 | Una consumable for Unagi instrument, 0.5 – 8 mL capacity. MWCO: 100kDa, regenerated cellulose (RC). 8 Unas per box, 5 boxes, case total of 40. |
| 901-2004 | Una PES, 30 kDa MWCO, case of 40 | Una consumable for Unagi instrument, 0.5 – 8 mL capacity. MWCO: 30kDa, polyethersulfone (PES). 8 Unas per box, 5 boxes, case total of 40. |
| 901-2005 | Una PES, 100 kDa MWCO, case of 40 | Una consumable for Unagi instrument, 0.5 – 8 mL capacity. MWCO: 100kDa, polyethersulfone (PES). 8 Unas per box, 5 boxes, case total of 40. |
| 901-2011 | Una RC, 10 kDa MWCO, case of 200 | Una consumable for Unagi instrument, 0.5 – 8 mL capacity. MWCO: 10kDa, regenerated cellulose (RC). 8 Unas per box, 25 boxes, case total of 200. |
| 901-2012 | Una RC, 30 kDa MWCO, case of 200 | Una consumable for Unagi instrument, 0.5 – 8 mL capacity. MWCO: 30kDa, regenerated cellulose (RC). 8 Unas per box, 25 boxes, case total of 200. |
| 901-2013 | Una RC, 100 kDa MWCO, case of 200 | Una consumable for Unagi instrument, 0.5 – 8 mL capacity. MWCO: 100kDa, regenerated cellulose (RC). 8 Unas per box, 25 boxes, case total of 200. |
| 901-2014 | Una PES, 30 kDa MWCO, case of 200 | Una consumable for Unagi instrument, 0.5 – 8 mL capacity. MWCO: 30kDa, polyethersulfone (PES). 8 Unas per box, 25 boxes, case total of 200. |
| 901-2015 | Una PES, 100 kDa MWCO, case of 200 | Una consumable for Unagi instrument, 0.5 – 8 mL capacity. MWCO: 100kDa, polyethersulfone (PES). 8 Unas per box, 25 boxes, case total of 200. |
| 901-2020 | Falcon Tubes | Buffer and sample Falcon brand tubes for Unagi instrument, 50mL capacity, case of 500. |
| 901-2031 | Unagi 1mL pipette tips, 100 tip racks | 1mL consumable pipette tips for Unagi instrument, clear. 100 tip racks, 9600 total tips. |
| Product Code | Product Name | Description |
| 201-1014 | Uni Filling Tool | Uni Filling Tool for easy filling of Unis when using a 16 channel pipette (pipette not included). |
| Product Code | Product Name | Description |
| 201-1007 | 10 Unis | Box of 10 Unis consisting of 16 x 9 µL micro cuvettes. Includes silicone seals. |
| 201-1008 | 30 Unis | Box of 30 Unis consisting of 16 x 9 µL micro cuvettes. Includes silicone seals. |
| 201-1009 | 60 Unis | Box of 60 Unis consisting of 16 x 9 µL micro cuvettes. Includes silicone seals. |
| 201-1010 | 120 Unis | Box of 120 Unis consisting of 16 x 9 µL micro cuvettes. Includes silicone seals. |
| 201-1011 | Uni Starter Pack | Starter pack contains 10 Unis, 20 silicone seals, 1 Uni Filling Tool, and 3 Uni Frames. |
| 201-1012 | 3 Uni Frames | Box of 3 Uni frames. One frame required per Uni to secure and seal micro cuvettes during use. Required for use with Unis in Uncle and Unit. |
| 201-1013 | 60 silicone seals | Pack of 60 silicone seals for use with Uni frames. |
| 201-1020 | Uncle Calibration Standard for DLS | DLS calibration standard (500 µL, 1 vial) |
| 201-1030 | Coolant Refill | 700 mL Coolant refill for coolant reservoir |