Cell Health

Cell Health
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Cell Health and Metabolism


 

Cell Health and Metabolism Categories

ADME Assays

Our wide selection of bioluminescent enzyme substrates for

proteases and metabolic enzymes such as CYPs and MAO, among

others, provide powerful tools for the ADME-Tox screen.

Apoptosis

Get more data in less time when you multiplex cell health biomarkers.

Measure one or multiple biomarkers in vitro or in situ todetect early or

late events of apoptosis and get a quick status update on targeted cells.

Cell Viability Assays

Easily compare the number of live cells/number of dead cells in a single well

to get better consistency of data. Normalized data allows data to be easily

compared from well-to-well, plate-to-plate and day-to-day.

Cytotoxicity Assays

Promega offers multiple readouts for quantifying cytotoxicity,

including luminescent and fluorescent assays that can be multiplexed

with apoptosis or viability assays to help determine mechanism of cell death.

Inflammation Assay

Caspase-1 is an essential component of the inflammasome. Conversion of the procaspase-1 zymogen into catalytically active caspase-1 results in 1) the processing and release of cytokines, IL-1β and IL-18, and 2) pyroptosis, an immunogenic form of cell death. Promega introduces a homogenous, bioluminescent method to selectively measure caspase-1 activity directly from cells or medium.

Metabolism Assays

NAD+, NADP+, NADH and NADPH are important cofactors for many enzymes involved in key cellular pathways, and quantitation of these dinucleotides is a standard approach to monitor enzyme activity directly or indirectly. Promega offers a number of systems to detect and quantify these important molecules.

Mitochondrial Function Assays

A multiplexed, cell-based assay to monitor mitochondrial health. Measures ATP and a membrane integrity biomarker to distinguish mito-toxic mechanisms from other cytotoxic events.

Oxidative Stress Assays

Promega offers assays for detecting glutathione, measuring the ratio of reduced to oxidized glutathione and detecting changes in ROS as an indicator of cell health or cell signaling events.

Toxicity Pathway Analysis

Reporter vectors and cell lines containing response elements for monitoring activity of key cell signaling pathways.

 

More; http://worldwide.promega.com/products/cell-health-and-metabolism/